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P2D92 - Metabolism of dexfenfluramine in vitro is dependent on CYP2D6

✍ Scribed by VS. Haritos; M.S. Ching; H. Ghabrial; A.S. Gross; J.T. Ahokas

Book ID
119540202
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
138 KB
Volume
95
Category
Article
ISSN
0378-4274

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## Abstract ## Objective Risperidone is converted to 9‐hydroxyrisperidone by CYP2D6. Two parameters were used to examine the influences of CYP2D6 polymorphism and of co‐medication on risperidone metabolism: the risperidone:9‐hydroxyrisperidone concentration ratio (R:9‐OHR ratio) and the sum of the