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P2A35 - Effects of environmental factors on extrahepatic Cyp2e1 gene expression in mice

✍ Scribed by E. Sampol; P.H. Villard; F. Puyoou; E.M. Sérée; H. Point-Scoma; B. Lacarelle; A. Durand

Book ID
119540145
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
140 KB
Volume
95
Category
Article
ISSN
0378-4274

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## Abstract Cytochrome P450 (CYP) 2A6 and __CYP2E1__ are enzymes with a high ability to activate a nitrosamine, 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (NNK), to its potent and ultimate carcinogens. The polymorphic __CYP2A6__ and __CYP2E1__ have been implicated in increased susceptibility to