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p27Kip1 ubiquitination and degradation is regulated by the SCFSkp2 complex through phosphorylated Thr187 in p27

✍ Scribed by Lyuben M. Tsvetkov; Kun-Huei Yeh; Soo-Jung Lee; Hong Sun; Hui Zhang


Book ID
114321637
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
102 KB
Volume
9
Category
Article
ISSN
0960-9822

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## Abstract Excessive cellular proliferation is thought to contribute to neointimal lesion development during atherosclerosis and restenosis after angioplasty. Inhibition of cyclin‐dependent kinase (CDK) activity by p27 inhibits mammalian cell growth. Mounting evidence indicates that p27 negatively