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p27Kip1: Regulation and Function of a Haploinsufficient Tumor Suppressor and Its Misregulation in Cancer

โœ Scribed by Jeannette Philipp-Staheli; Shannon R. Payne; Christopher J. Kemp

Book ID
115603932
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
286 KB
Volume
264
Category
Article
ISSN
0014-4827

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Cyclin-dependent kinases (CDKs), together with cyclins, their regulatory subunits, govern cell-cycle progression in eukaryotic cells. p27(Kip1) is a member of a family of CDK inhibitors (CDIs) that bind to cyclin/CDK complexes and arrest cell division. There is considerable evidence that p27(Kip1) p