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P268 UR-1505, A NEW SALICYLATE DERIVATIVE, SHOWS INTESTINAL ANTI-INFLAMMATORY ACTIVITY IN THE CHRONIC PHASE OF THE DSS MODEL OF RAT COLITIS

✍ Scribed by E. Bailon; M. Comalada; M. Sarasa; J. Roman; P. Michelena; D. Balsa; M. Merlos; A. Nieto; A. Concha; A. Zarzuelo; J. Gálvez

Book ID
119637465
Publisher
Oxford University Press
Year
2008
Weight
71 KB
Volume
2
Category
Article
ISSN
1873-9954

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UR-1505, a salicylate able to selectively block T-cell activation, shows intestinal anti-inflammatory activity in the chronic phase of the DSS model of rat colitis
✍ Elvira Bailón; Mònica Comalada; Juan Román; Pedro Michelena; Isabel Ramis; Manue 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 339 KB

Background: UR-1505 is a novel salicylate derivative compound that has been demonstrated to selectively down-regulate T-cell activation. The aim of the present study was to elucidate the mechanisms involved in the intestinal anti-inflammatory effects of UR-1505 in 2 protocols of a dextran sodium sul