Intestinal anti-inflammatory activity of UR-12746, a novel 5-ASA conjugate, on acute and chronic experimental colitis in the rat

UR-1505, a salicylate able to selectivel

UR-1505, a salicylate able to selectively block T-cell activation, shows intestinal anti-inflammatory activity in the chronic phase of the DSS model of rat colitis

✍ Elvira Bailón; Mònica Comalada; Juan Román; Pedro Michelena; Isabel Ramis; Manue 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 339 KB

Background: UR-1505 is a novel salicylate derivative compound that has been demonstrated to selectively down-regulate T-cell activation. The aim of the present study was to elucidate the mechanisms involved in the intestinal anti-inflammatory effects of UR-1505 in 2 protocols of a dextran sodium sul