During development, bone morphogenetic proteins (BMPs) induce the differentiation of mesenchymal progenitor cells to enter into the osteoblastic lineage, and BMPs enhance osteoblastic function. BMPs and noggin, a specific binding protein that blocks BMP actions, are expressed by osteoblastic cells b
โฆ LIBER โฆ
P22. Regulation of gene expression in osteoblasts by bone morphogenetic protein 4
โ Scribed by Goodman, SA; Burrin, JM; Hughes, FJ
- Book ID
- 123094878
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 149 KB
- Volume
- 15
- Category
- Article
- ISSN
- 8756-3282
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We have examined the effects of BMP-2 on the expression of bone matrix proteins in both human bone marrow stromal cells (HBMSC) and human osteoblasts (HOB) and their proliferation and mineralization. Both HBMSC and HOB express BMP-2/-4 type I and type II receptors. Treatment of these two cell types