p21Waf1/Cip1/Sdi1 mediates retinoblastoma protein degradation
โ Scribed by Broude, E V; Swift, M E; Vivo, C; Chang, B-D; Davis, B M; Kalurupalle, S; Blagosklonny, M V; Roninson, I B
- Book ID
- 110072511
- Publisher
- Nature Publishing Group
- Year
- 2007
- Tongue
- English
- Weight
- 172 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0950-9232
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p2lMIAFlICIPlISDIl is an important cell-cycle mediator with tumor suppressor gene capabilities, and its inactivation could potentially lead to tumor progression. Because tumor suppressor genes are commonly inactivated by somatic and germline mutations, we analyzed a variety of human tumor cell lines
WAF1/Cip1/Sdi1 (p21) is the prototype of a family of proteins that inhibit cyclin-dependent kinases and regulate cell cycle progression in eukaryotic cells. In addition to normal cell cycle progression, p21 is involved in growth suppression mediated by p53 and transforming growth factor beta (TGFbet