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p21 (WAF1/CIP1) Protein Expression Is Associated with Prolonged Survival but Not with p53 Expression in Epithelial Ovarian Carcinoma

✍ Scribed by Annette Schmider; Conway Gee; Wolfgang Friedmann; Jason J. Lukas; Michael F. Press; Werner Lichtenegger; Angela Reles

Book ID
112248059
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
177 KB
Volume
77
Category
Article
ISSN
0090-8258

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Defects in the mechanisms controlling the cell cycle are crucial in cell transformation and/or tumour progression. p21 WAF1/CIP1 is an inhibitor of cyclin-dependent kinases, induced by p53-dependent and p53-independent pathways, which can block progression through the cell cycle. p21 WAF1/CIP1 expre