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P2-211: Genome-wide association study identifies genetic risk factors for variant Creutzfeldt-Jakob disease

✍ Scribed by Mead, Simon; Poulter, Mark; Uphill, James; Beck, John; Webb, Thomas; Campbell, Tracy; Adamson, Gary; Molonou, Eleni; Hummerich, Holger; Verzilli, Claudio; Whittaker, John; Collinge, John


Book ID
123594669
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
60 KB
Volume
4
Category
Article
ISSN
1552-5260

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A genome-wide association study for celi
✍ van Heel, David A; Franke, Lude; Hunt, Karen A; Gwilliam, Rhian; Zhernakova, Ale πŸ“‚ Article πŸ“… 2007 πŸ› Nature Publishing Group 🌐 English βš– 211 KB

We tested 310,605 SNPs for association in 778 individuals with celiac disease and 1,422 controls. Outside the HLA region, the most significant finding (rs13119723; P ΒΌ 2.0 Γ‚ 10 -7 ) was in the KIAA1109-TENR-IL2-IL21 linkage disequilibrium block. We independently confirmed association in two further