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P2-026: The cholesterol transporter ABCG1 modulates the proteolytic processing of amyloid precursor protein

✍ Scribed by Gavin Tansley; Braydon L. Burgess; Matt Bryan; Yuan Su; Jeniffer Y. Chan; Kathryn E. Naus; Sean McIsaac; Veronica Hirsch-Reinshagen; Hsui-Chiung Yang; Ronald B. DeMattos; Cheryl L. Wellington


Book ID
118462931
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
68 KB
Volume
2
Category
Article
ISSN
1552-5260

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## Abstract Proteolytic processing of the amyloid precursor protein by Ξ² ‐and γ‐secretases results in the production of Alzheimer's disease (AD) AΞ² amyloid peptides. Modulation of secretase activity is being investigated as a potential therapeutic approach. Recent studies with human brain have reve