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p16INK4a induces an age-dependent decline in islet regenerative potential

✍ Scribed by Krishnamurthy, Janakiraman; Ramsey, Matthew R.; Ligon, Keith L.; Torrice, Chad; Koh, Angela; Bonner-Weir, Susan; Sharpless, Norman E.


Book ID
109896129
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
438 KB
Volume
443
Category
Article
ISSN
0028-0836

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## Abstract Elevation of p16^INK4a^ has been described as an important mechanism for hydrogen peroxide (H~2~O~2~)‐induced replicative senescence. However, the mechanisms underlying remain unknown. In this study, we demonstrate an important role of RNA‐binding protein AUF1‐mediated mRNA turnover in