p16INK4a Expression does not predict the outcome of cervical intraepithelial neoplasia grade 2
✍ Scribed by A.C. GUEDES; S.M.F. BRENNA; S.A.S. COELHO; E.Z. MARTINEZ; K.J. SYRJÄNEN; L.C. ZEFERINO
- Book ID
- 109086102
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 95 KB
- Volume
- 17
- Category
- Article
- ISSN
- 1048-891X
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## Abstract ## BACKGROUND The primary goal of this study was to compare the clinical performance of an optimized and rigorously controlled immunocytochemical (ICC) assay for p16^INK4a^ to high‐risk (HR) human papillomavirus (HPV) detection by polymerase chain reaction (PCR) as diagnostic adjuncts
Specific antibodies against the C-terminus of E2, produced by affinity purification of polyclonal antisera, have been used to identify the cellular populations which express the HPV 16 E2 transcription factor, in a series of formalin-fixed, paraffin-embedded cervical tissues. Cases were selected for