P163 β1-INTEGRIN REGULATION OF MECHANOTRANSDUCTIONIN OSTEOARTHRITIC HUMAN ARTICULAR CHONDROCYTES
✍ Scribed by K.J. Elliot; D.M. Salter
- Book ID
- 114349510
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 57 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1063-4584
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## Abstract ## Objective Chondrocyte cell death may play an important role in the development of arthritis. The goal of the present study was to evaluate the role of the extracellular matrix (ECM) in promoting chondrocyte survival via signals through the integrin family of ECM receptors. ## Metho
Objective. To investigate the role of interleukin-6 (IL-6) and transforming growth factor pl (TGFp1) in the regulation of tissue inhibitor of metalloproteinases-1 (TIMP-1) synthesis in human articular chondrocytes. Methods. Articular cartilage was obtained from human knee joints 24 hours after deat