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P12 Plasminogen activator inhibitor-1, thrombophilia in women with metabolic syndrome

✍ Scribed by T.B. Pshenichnikova; E.B. Perederyaeva

Book ID: 117258053
Publisher: Elsevier Science
Year: 2009
Tongue: English
Weight: 57 KB
Volume: 123
Category: Article
ISSN: 0049-3848
DOI: 10.1016/s0049-3848(09)70057-x

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## Abstract Plasminogen activator inhibitor‐1 (PAI‐1) is a physiological inhibitor of urokinase (uPA), a serine protease known to promote cell migration and invasion. Intuitively, increased levels of PAI‐1 should be beneficial in downregulating uPA activity, particularly in cancer. By contrast, in