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P1096 Is p16INK4A expression useful to determine the outcome of atypical squamous cells of undetermined significance

✍ Scribed by Douvier, S.; Thouvenot, S.; Filipuzzi, L.; Sagot, P.

Book ID
122274047
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
47 KB
Volume
107
Category
Article
ISSN
0020-7292

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## Abstract Even though p16^INK4a^ (p16) immunocytochemistry has proven a useful accessory tool verifying the identification of atypical squamous cells of undetermined significance (ASC‐US) categorized smears, the procedure still has limitations. To date few studies examining the usefulness of p16

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BACKGROUND. P16 INK4a (p16) has emerged as a biomarker for the detection of high-risk human papillomavirus (HR-HPV) in Papanicolaou (Pap) smears. Many studies have confirmed a strong correlation between p16 immunohistochemical positivity and high-grade squamous intraepithelial lesions (HSIL) of the