Expression of p16INK4A in Papanicolaou smears containing atypical squamous cells of undetermined significance from the uterine cervix
β Scribed by Shin Nieh; Su-Feng Chen; Tang-Yuan Chu; Hung-Cheng Lai; Earl Fu
- Book ID
- 114101659
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 368 KB
- Volume
- 91
- Category
- Article
- ISSN
- 0090-8258
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BACKGROUND. P16 INK4a (p16) has emerged as a biomarker for the detection of high-risk human papillomavirus (HR-HPV) in Papanicolaou (Pap) smears. Many studies have confirmed a strong correlation between p16 immunohistochemical positivity and high-grade squamous intraepithelial lesions (HSIL) of the
## Abstract Even though p16^INK4a^ (p16) immunocytochemistry has proven a useful accessory tool verifying the identification of atypical squamous cells of undetermined significance (ASCβUS) categorized smears, the procedure still has limitations. To date few studies examining the usefulness of p16
## BACKGROUND. Recommendations for the proper treatment of women diagnosed with an equivocal atypical squamous cells of undetermined significance (ASCUS) Papanicolaou (Pap) smear are controversial. To the authors' knowledge, there currently are no methods available that can identify accurately ASC