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Expression of p16INK4A in Papanicolaou smears containing atypical squamous cells of undetermined significance from the uterine cervix

✍ Scribed by Shin Nieh; Su-Feng Chen; Tang-Yuan Chu; Hung-Cheng Lai; Earl Fu


Book ID
114101659
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
368 KB
Volume
91
Category
Article
ISSN
0090-8258

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BACKGROUND. P16 INK4a (p16) has emerged as a biomarker for the detection of high-risk human papillomavirus (HR-HPV) in Papanicolaou (Pap) smears. Many studies have confirmed a strong correlation between p16 immunohistochemical positivity and high-grade squamous intraepithelial lesions (HSIL) of the

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## BACKGROUND. Recommendations for the proper treatment of women diagnosed with an equivocal atypical squamous cells of undetermined significance (ASCUS) Papanicolaou (Pap) smear are controversial. To the authors' knowledge, there currently are no methods available that can identify accurately ASC