P.1.034 In vivo study in humans on disposition of the enantiomers and metabolites of mirtazapine
β Scribed by L. Delbressine; M.-L. Dahl; H.M. van den Wildenberg; H.J. Kleijn; L. Bertilsson
- Book ID
- 118599772
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 138 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0924-977X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract A stereospecific highβperformance liquid chromatographic (HPLC) method was developed for the quantitation of the enantiomers of venlafaxine, an antidepressant, in dog, rat, and human plasma. The procedure involves derivatization of venlafaxine with the chiral reagent, (+)βSβnaproxen chl
The steady-state pharmacokinetics in serum and urine of the enantiomers of citalopram and its metabolites, demethylcitalopram (DCT) and didemethylcitalopram (DDCT), were investigated after multiple doses of rac-citalopram for 21 consecutive days (40 mg per day) to healthy human subjects who were ext