i) The urinary elimination of methoxyphenamine (MPA) and its metabolites in underivatized samples was examined after single and multiple oral administration to pregnant and non-pregnant mice by GLC and GLC-MS. (ii) The major metabolite 0-desmethylmethoxyphenamine (ODMP), along with lesser amounts of
Influence of urinary pH on the disposition of methoxyphenamine and three metabolites in humans
β Scribed by S. D. Roy; E. M. Hawes; K. K. Midha
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 623 KB
- Volume
- 76
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The effect of food on the pharmacokinetics of the antiepileptic oxcarbazepine (OXC) was investigated in healthy volunteers. Six healthy male volunteers were treated with single peroral doses of 600 mg of oxcarbazepine (Trileptal@) after overnight fasting or a fat-and protein-rich breakfast. Mean ( k
## Abstract After the intraperitoneal administration of high doses of ^14^Cβ and ^3^Hβlabelled retinoic acid (**1**) to rats three major urinary metabolites have been isolated in microgram amounts by use of column, thinβlayer and highβpressure liquid chromatography. Their structures were elucidated
## Abstract The pharmacokinetics of moricizine and two of its metabolites, moricizine sulfoxide and phenothiazineβ2βcarbamic acid ethyl ester sulfoxide, were studied in healthy control subjects and in patients with chronic liver disease (cirrhosis). Moricizine disposition was significantly altered