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P1-360: Plasma ceramides are altered early in the course of Alzheimer's disease

✍ Scribed by Michelle M. Mielke; Veera V.R. Bandaru; Norman J. Haughey; Steven Schech; Michael Chu; Marilyn Albert; Karen Bandeen-Roche; Constantine G. Lyketsos

Book ID
118464520
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
49 KB
Volume
4
Category
Article
ISSN
1552-5260

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## Abstract The degradation of aberrantly phosphorylated tau in neurons plays an important role in the pathogenesis of Alzheimer's disease (AD). hHrd1 is a newly identified ubiquitin ligase involved in the endoplasmic reticulum (ER)‐associated protein degradation. The expression and function of hHr