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P XVI B.4 - P XVI B.4 O6-methylguanine is a ubiquitous lesion in human DNA

✍ Scribed by P. Georgiadis; S. Kaila; E. Samoli; K. Katsouyanni; S.A. Kyrtopoulos

Book ID
114072090
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
222 KB
Volume
379
Category
Article
ISSN
0027-5107

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The O 6 -methylguanine-DNA-methyltransferase (MGMT) inactivator O 6benzylguanine (O 6 -beG) is currently under clinical investigation as a potential tumour-sensitising agent. In clinical trials its use has been associated with increased myelotoxicity and a reduced maximum tolerated dose (MTD) for BC