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P XI B.1 - P XI B.1 DNA repair of UV photoproducts and mutagenesis in human mitochondrial DNA

✍ Scribed by B. Pascucci; A. Varsteegh; A. van der Leer-van Hoffen; A.A. van Zeeland; L.H.F. Mullenders; E. Dogliotti

Book ID
114071800
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
98 KB
Volume
379
Category
Article
ISSN
0027-5107

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## Abstract O^6^‐methylguanine‐DNA methyltransferase (MGMT) is a repair protein that specifically removes promutagenic alkyl groups from the O^6^ position of guanine in DNA. __MGMT__ is transcriptionally silenced by promoter hypermethylation in several human cancers. Methylation‐specific PCR (MSP)