P-glycoprotein expression in soft-tissue sarcomas
β Scribed by Hirofumi Nakanishi; Akira Myoui; Takahiro Ochi; Katsuyuki Aozasa
- Publisher
- Springer-Verlag
- Year
- 1997
- Tongue
- English
- Weight
- 819 KB
- Volume
- 123
- Category
- Article
- ISSN
- 1432-1335
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Twenty-two fresh surgical specimens of human sarcomas (soft tissue and bone) from 20 patients were analyzed by flow cytometry for the expression of drug resistance-related P-glycoprotein (P-gp) and cellular daunorubicin (DNR) accumulation with or without the presence of DNR efflux blockers. Single-c
## Abstract Monospecific antibodies and indirect immunofluorescence microscopy were used to investigate the presence of cytoskeletal intermediate filaments of the keratin, vimentin and desmin types in 43 softβtissue sarcomas. The results showed that vimentin was present in the neoplastic cells of a