𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Expression of intermediate filaments in soft-tissue sarcomas

✍ Scribed by M. Miettinen; V.-P. Lehto; R. A. Badley; I. Virtanen

Publisher
John Wiley and Sons
Year
1982
Tongue
French
Weight
837 KB
Volume
30
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Monospecific antibodies and indirect immunofluorescence microscopy were used to investigate the presence of cytoskeletal intermediate filaments of the keratin, vimentin and desmin types in 43 soft‐tissue sarcomas. The results showed that vimentin was present in the neoplastic cells of all types of soft‐tissue sarcomas studied, whereas keratin was absent, the only exception being the epithelial‐like cells in biphasic synovial sarcoma. The presence of desmin was confined to leiomyosarcomas and rhabdomyosarcomas, which usually showed desmin‐positivity. In addition, malignant fibrous histiocytomas occasionally displayed some desmin‐positive cells. Thus, determination of intermediate filaments is of aid in the histogenetical diagnosis of tumors, because keratin‐positivity largely excludes the possibility of a sarcoma, and desmin‐positivity aids in recognizing leiomyosarcomas and rhabdomyosarcomas.

📜 SIMILAR VOLUMES

Soft tissue sarcomas in children
Soft tissue sarcomas in children
✍ Alberto S. Papp; David M. Parham; Bhaskar N. Rao; Thom E. Lobe 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 761 KB

In childhood, soft tissue sarcomas comprise a complex group of malignancies of varied histologic subtypes, the prognoses of which depend on the histology, age, site, extent of involvement and a variety of other factors. This paper discusses the varieties of tumors classified as soft tissue sarcomas

Prognostic significance of CD100 express
Prognostic significance of CD100 expression in soft tissue sarcoma
✍ EweSeng Ch'ng; Yasuhiko Tomita; Binglin Zhang; Juxiang He; Yoshihiko Hoshida; Yi 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 301 KB 👁 1 views

## Abstract ## BACKGROUND. CD100, a class IV semaphorin, promotes angiogenesis, invasive growth, proliferation, and antiapoptosis of cancer cells in vitro. The expression of CD100 in soft tissue sarcoma (STS) and its correlation with clinicopathologic factors and prognostic significance were evalu

Prognosticators in thigh soft tissue sar
Prognosticators in thigh soft tissue sarcomas
✍ Anne E. Newcomer; Diane Dylinski; Brian P. Rubin; Michael J. Joyce; Gerald Hoelt 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 121 KB

## Abstract ## Background In sarcoma patients the roles of smoking history, family cancer history, and leukoreduced blood transfusions have not been studied and the effect of preoperative radiation on blood loss has not been examined. ## Methods Seventy‐seven patients with non‐metastatic and non

Intrathoracic soft tissue sarcomas in ch
Intrathoracic soft tissue sarcomas in children
✍ William M. Crist; R. Beverly Raney Jr.; William Newton; Walter Lawrence Jr.; Mel 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 English ⚖ 574 KB
Intratumor versus intertumor heterogenei
Intratumor versus intertumor heterogeneity in gene expression profiles of soft-tissue sarcomas
✍ Princy Francis; Josefin Fernebro; Patrik Edén; Anna Laurell; Anders Rydholm; Hen 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 216 KB

## Abstract Soft‐tissue sarcomas (STSs) constitute more than 30 histologic entities. In addition, within each entity, tumors are often heterogeneous in macroscopic features, genetic alterations, microscopic appearance, and clinical course. Therefore, there has been concern about whether a single tu