𝔖 Bobbio Scriptorium
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P-glycoprotein does not actively transport nicotine and cotinine

✍ Scribed by Jun-Sheng Wang; John Markowitz; Jennifer Donovan; C Lindsay Devane


Book ID
111739779
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
135 KB
Volume
10
Category
Article
ISSN
1355-6215

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The blood-brain barrier (BBB) transport of naloxone, a potent and specific opioid antagonist, was investigated in rats using the brain uptake index method and the brain efflux index method. The apparent influx clearance of [ 3 H]naloxone across the BBB was 0.305 mL/min/g brain. [ 3 H]naloxone was el