Bloodβbrain barrier transport of naloxon
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Toyofumi Suzuki; Mariko Miyata; Chika Zaima; Takayuki Furuishi; Toshiro Fukami;
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Article
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2010
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John Wiley and Sons
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English
β 137 KB
The blood-brain barrier (BBB) transport of naloxone, a potent and specific opioid antagonist, was investigated in rats using the brain uptake index method and the brain efflux index method. The apparent influx clearance of [ 3 H]naloxone across the BBB was 0.305 mL/min/g brain. [ 3 H]naloxone was el