P-951 Combined ADM of antisense chemoradioimmunotherapy(ACRIT) consisting of antiHER2 scFv linked onto high energy radioisotopes and triplex forming oligonucleotides (TFO) targeted to DNMT1 and conjugated to vinorelbine tartrate induce apoptosis in metastatic NSCLC characterised by hypermethylated oncosuppressor genes VHL, p53, p16, RASSF1A, Rar-b2, TIMP3, PTEN, H-cadherin, BRCA2, p14ARF and overexpression of HIF-1, VEGF, MMP-2, MMP-9, Glut-1, IGF1R, bcl-2, cdc25c, Raf-1, TGFa, UPAR, c-met and EGFR

✍ Scribed by Giannios, J.; Michailakis, E.; Ginopoulos, P.

• Book ID: 122029142
• Publisher: Elsevier Science
• Year: 2005
• Tongue: English
• Weight: 147 KB
• Volume: 49
• Category: Article
• ISSN: 0169-5002
• DOI: 10.1016/S0169-5002(05)81444-8