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P-657 Cyclin D1, a potential therapeutic target is over-expressed in a high proportion of non small cell lung cancer

✍ Scribed by Bebb, Gwyn; Au, Nicholas; Cheang, Maggie; Tucker, Catherine; Flint, Julia; English, John; Murray, Nevin

Book ID: 118572351
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 158 KB
Volume: 41
Category: Article
ISSN: 0169-5002
DOI: 10.1016/s0169-5002(03)92624-9

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## Inactivation of the Rb pathway in non-small cell lung carcinoma (NSCLC) occurs mostly through inactivation of the cyclin-dependent kinase inhibitor p16 INK4A and/or up-regulation of cyclin D1. In order to assess the frequency and the prognostic value of these abnormalities in NSCLC, immunohisto