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P-633 Non-small cell lung cancer (NSCLC) patients with undetectable epidermal growth factor receptor (EGFR) expression respond poorly to ZD1839 (Iressa)

โœ Scribed by Polowy, Clayton R.; Coon, John S.; Leslie, William T.; DiNunno, Lucio; Lukic, Ivanka; Kanevsky, Gina; Gale, Meryl; Morrison, Larry E.; Seelig, Steven A.; Bonomi, Philip


Book ID
118572328
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
184 KB
Volume
41
Category
Article
ISSN
0169-5002

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## Abstract Gefitinib has shown meaningful antitumor activity with tolerable toxicity in chemotherapyโ€refractory NSCLC in previous studies. Moreover, EGFR expression failed to show a correlation with response. In an attempt to identify predictive markers of response, we have investigated the tumora