Epidermal growth factor receptor (EGFR) mutations in a series of non-small-cell lung cancer (NSCLC) patients and response rate to EGFR-specific tyrosine kinase inhibitors (TKIs)
✍ Scribed by Elena María Martínez-Navarro; Joseba Rebollo; Ramón González-Manzano; Manuel Sureda; Elena Evgenyeva; Belén Valenzuela; Francisco José Fernández; Jerónimo Forteza; Antonio Brugarolas
- Publisher
- Springer Milan
- Year
- 2011
- Tongue
- Spanish
- Weight
- 230 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1699-048X
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## Abstract ## BACKGROUND: Somatic mutations in the epidermal growth factor receptor (EGFR) kinase domain are associated with sensitivity to EGFR‐tyrosine kinase inhibitors (EGFR‐TKI) in patients with nonsmall cell lung cancer (NSCLC). ## METHODS: The authors tested the possibility that nucleoti
## Abstract The high frequency of epidermal growth factor receptor (__EGFR__) mutations in tyrosine kinase inhibitor‐responsive non‐small‐cell lung cancer (NSCLC) cases is now well established, highlighting the predictive value of activating __EGFR__ mutations in guiding the clinical use of __EGFR_