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P-2-10 - Reversible metabolism of clozapine and clozapine N-oxide

✍ Scribed by W.H. Chang; S.K. Lin; H.Y. Lane; F.C. Wei; W.H. Hu; Y.W.F. Lang; M.W. Jann


Book ID
119177173
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
148 KB
Volume
6
Category
Article
ISSN
0924-977X

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Pooled plasma from healthy volunteers was spiked with pure, synthetic clozapine or clozapine N-oxide and then made alkaline with either sodium hydroxide or sodium carbonate. The alkalized samples were allowed to stand at room temperature for various time intervals before extraction with organic solv