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Oxyma: An Efficient Additive for Peptide Synthesis to Replace the Benzotriazole-Based HOBt and HOAt with a Lower Risk of Explosion[1]

✍ Scribed by Ramon Subirós-Funosas; Rafel Prohens; Rafael Barbas; Ayman El-Faham; Fernando Albericio

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
497 KB
Volume
15
Category
Article
ISSN
0947-6539

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📜 SIMILAR VOLUMES

ChemInform Abstract: Ethyl 2-Cyano-2-(hy
ChemInform Abstract: Ethyl 2-Cyano-2-(hydroxyimino)acetate (Oxyma): An Efficient and Convenient Additive Used with Tetramethylfluoroformamidinium Hexafluorophosphate (TFFH) to Replace 1-Hydroxybenzotriazole (HOBt) and 1-Hydroxy-7-azabenzotriazole (HOAt) During Peptide Synthesis.
✍ Sherine N. Khattab 📂 Article 📅 2011 🏛 John Wiley and Sons ⚖ 20 KB

## Abstract High coupling yields and a racemization depression are observed using a combination of Oxyma and TFFH in solution‐ and solid‐phase peptide synthesis.