ChemInform Abstract: Ethyl 2-Cyano-2-(hydroxyimino)acetate (Oxyma): An Efficient and Convenient Additive Used with Tetramethylfluoroformamidinium Hexafluorophosphate (TFFH) to Replace 1-Hydroxybenzotriazole (HOBt) and 1-Hydroxy-7-azabenzotriazole (HOAt) During Peptide Synthesis.

✍ Scribed by Sherine N. Khattab

• Publisher: John Wiley and Sons
• Year: 2011
• Weight: 20 KB
• Volume: 42
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.201106203

✦ Synopsis

Abstract

High coupling yields and a racemization depression are observed using a combination of Oxyma and TFFH in solution‐ and solid‐phase peptide synthesis.