ChemInform Abstract: Sulfonate Esters of 1-Hydroxypyridin-2(1H)-one and Ethyl 2-Cyano-2-(hydroxyimino)acetate (Oxyma) as Effective Peptide Coupling Reagents to Replace 1-Hydroxybenzotriazole and 1-Hydroxy-7-azabenzotriazole.

ChemInform Abstract: Ethyl 2-Cyano-2-(hy

ChemInform Abstract: Ethyl 2-Cyano-2-(hydroxyimino)acetate (Oxyma): An Efficient and Convenient Additive Used with Tetramethylfluoroformamidinium Hexafluorophosphate (TFFH) to Replace 1-Hydroxybenzotriazole (HOBt) and 1-Hydroxy-7-azabenzotriazole (HOAt) During Peptide Synthesis.

✍ Sherine N. Khattab 📂 Article 📅 2011 🏛 John Wiley and Sons ⚖ 20 KB

## Abstract High coupling yields and a racemization depression are observed using a combination of Oxyma and TFFH in solution‐ and solid‐phase peptide synthesis.