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Oxygen-enhanced proton imaging of the human lung using T2*

✍ Scribed by Eberhard D. Pracht; Johannes F. T. Arnold; Tungte Wang; Peter M. Jakob

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
184 KB
Volume
53
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

Magnetic susceptibility gradients caused by tissue/air interfaces lead to very short T~2~* times in the human lung. These susceptibility gradients are dependent on the magnetic susceptibility of the respiratory gas and therefore should influence T~2~* relaxation. In this work, a technique for quantitative T~2~* mapping of the human lung during one breath hold is presented. Using this method, the lung T~2~* relaxation time was measured under normoxic (room air, 21% O~2~) and hyperoxic (100% O~2~) conditions to verify this assumption. The mean T~2~* difference between room air and 100% O~2~ is about 10% and contains ventilation information, since only ventilated regions contribute to signal change due to different susceptibility gradients. Magn Reson Med 53:1193–1196, 2005. © 2005 Wiley‐Liss, Inc.

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