Oxygen activation by iron ribonucleotide reductase
β Scribed by J. Sanders-Loehr; J. Ling; T.M. Loehr; M. Sahlin; B.-M. Sjoberg
- Book ID
- 103569459
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 68 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0162-0134
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## Abstract This article focuses on the first step of the catalytic mechanism for the reduction of ribonucleotides catalyzed by the enzyme Ribonucleotide Reductase (RNR). This corresponds to the activation of the substrate. In this work a large model of the active site region involving 130 atoms wa
New insights have been gained into the formation of the di-iron tyrosyl radical cofactor, which is essential for nucleotide reduction in the class I ribonucleotide reductases. Recent advances include Insight into the function of the tyrosyl radical in initiation of nucleotide reduction.