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Oxidative Stress, Lipid Rafts, and Macrophage Reprogramming

✍ Scribed by Cuschieri, Joseph; Maier, Ronald V.


Book ID
115533375
Publisher
Mary Ann Liebert
Year
2007
Tongue
English
Weight
360 KB
Volume
9
Category
Article
ISSN
1523-0864

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## Abstract Oxidative stress is associated with β‐amyloid peptide (AΞ²) accumulation in the brains of Alzheimer's disease patients. AΞ² is generated upon the sequential proteolytic cleavage of transmembrane amyloid precursor protein (APP) by two membrane‐bound proteases, β‐secretase (BACE1) and the Ξ³