Homozygosity for the mutation Cys282Tyr in the HFE gene has recently been identified as a cause of hereditary hemochromatosis, a disorder resulting in the inappropriate absorption of iron. Approximately 10% of Caucasians are heterozygous for this mutation; however, the gene frequency in African Amer
Oxidative stress in asymptomatic subjects with hereditary hemochromatosis
β Scribed by Yukitaka Shizukuda; Charles D. Bolan; Tammy T. Nguyen; Gilberto Botello; Dorothy J. Tripodi; Yu-Ying Yau; Myron A. Waclawiw; Susan F. Leitman; Douglas R. Rosing
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 237 KB
- Volume
- 82
- Category
- Article
- ISSN
- 0361-8609
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## With the C282Y Mutation in the HFE Gene To the Editor: The association between hereditary hemochromatosis and thalassemia syndrome might lead to a severe iron overload [1,2], but the results are still controversial. By PCR and restriction enzyme digestion [3], we analyzed the C282Y and H63D muta
## BACKGROUND. Oxidative stress in tissues can be provoked by an augmented metabolic rate, which may sometimes be combined with a decrease in the antioxidant capacity. METHODS. In this study we examined the primary enzymatic defense mechanisms against the damage caused by reactive oxygen species (
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