Oxidative DNA damage in the aging mouse brain
β Scribed by Fernando Cardozo-Pelaez; Shijie Song; Anand Parthasarathy; Christopher Hazzi; Kamatham Naidu; Juan Sanchez-Ramos
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 145 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0885-3185
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In humans, cerebral hypoxia is a common component of severe brain insults, including trauma, stroke, and perinatal asphyxia. Oxidative stress and free radicals incidental to cerebral hypoxia are implicated in damaging macromolecules, leading to collapse of cellular homeostasis and cell death. Neuron