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Oxidative DNA damage and repair in teratogenesis and neurodevelopmental deficits

✍ Scribed by Peter G. Wells; Gordon P. McCallum; Kyla C. H. Lam; Jeffrey T. Henderson; Stephanie L. Ondovcik


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
336 KB
Volume
90
Category
Article
ISSN
1542-975X

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The OGG1 gene of Saccharomyces cerevisiae encodes a DNA glycosylase that excises 7,8-dihydro-8-oxoguanine (8-OxoG). When compared to wild-type, ogg1 mutants show an increase in the frequency of GC to TA transversions, indicating a role for Ogg1 in the repair of 8-OxoG. Here we report an increased fr