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Oxidative DNA Damage by a Metabolite of Carcinogenic 1-Nitropyrene

โœ Scribed by Shiho Ohnishi; Mariko Murata; Kiyoshi Fukuhara; Naoki Miyata; Shosuke Kawanishi


Book ID
115587168
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
95 KB
Volume
280
Category
Article
ISSN
0006-291X

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Oxidative DNA damage by a common metabol
โœ Mariko Murata; Yumiko Yoshiki; Mariko Tada; Shosuke Kawanishi ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 328 KB

Both carcinogenic NF and AAF are metabolized to a common N-hydroxy metabolite, N-OH-AF. We investigated oxidative DNA damage by N-OH-AF, using (32)P-labeled human DNA fragments from the human p53 and p16 tumor-suppressor genes and the c-Ha-ras-1 protooncogene. N-OH-AF caused Cu(II)-mediated DNA dama