Oxidative DNA damage by a common metabol
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Mariko Murata; Yumiko Yoshiki; Mariko Tada; Shosuke Kawanishi
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Article
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2002
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John Wiley and Sons
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French
โ 328 KB
Both carcinogenic NF and AAF are metabolized to a common N-hydroxy metabolite, N-OH-AF. We investigated oxidative DNA damage by N-OH-AF, using (32)P-labeled human DNA fragments from the human p53 and p16 tumor-suppressor genes and the c-Ha-ras-1 protooncogene. N-OH-AF caused Cu(II)-mediated DNA dama