Oxidative decarboxylation of naproxen
✍ Scribed by Francisco Boscá; Ramón Martínez-Mánez; Miguel A. Miranda; Jaime Primo; Juan Soto; Lirios Vaño
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 400 KB
- Volume
- 81
- Category
- Article
- ISSN
- 0022-3549
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📜 SIMILAR VOLUMES
## Abstract Cyclohexanecarboxylic acid is converted to a mixture of cyclohexanone and cyclohexene by reacting it at temperatures around 200° with an oxygen‐containing gas and steam in the presence of metal‐salt catalysts.
The antiinflammatory drug Naproxen has been synthesized via several enantioselective routes. The recently published synthesis involving the asymmetric decarboxylation of 2-cyano-2-(6-methoxy-naphth-2-yl)propionic acid (H. Brunner, P. Schmidt, Eur. J. Org. Chem. 2000, 2119) was investigated by quantu