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A Computational Study of the Stereoselective Decarboxylation in the Synthesis of Naproxen

✍ Scribed by Markus Drees; Lillian Kleiber; Martin Weimer; Thomas Strassner

Publisher: John Wiley and Sons
Year: 2002
Tongue: English
Weight: 124 KB
Volume: 2002
Category: Article
ISSN: 1434-193X
DOI: 10.1002/1099-0690(200207)2002:14<2405::aid-ejoc2405>3.0.co;2-1

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✦ Synopsis

The antiinflammatory drug Naproxen has been synthesized via several enantioselective routes. The recently published synthesis involving the asymmetric decarboxylation of 2-cyano-2-(6-methoxy-naphth-2-yl)propionic acid (H. Brunner, P. Schmidt, Eur. J. Org. Chem. 2000, 2119) was investigated by quantum-chemical calculations. It was found that the stereochemistry of the products was determined by a concerted protonation/decarboxylation reaction.

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