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Oxidative Damage of Rat Cerebral Cortex and Hippocampus, and Changes in Antioxidative Defense Systems Caused by Hyperoxia

✍ Scribed by Onodera, Koji; Omoi, Nao-Omi; Fukui, Koji; Hayasaka, Takahiro; Shinkai, Tadashi; Suzuki, Shozo; Abe, Kouichi; Urano, Shiro

Book ID: 121213836
Publisher: Informa plc
Year: 2003
Tongue: English
Weight: 157 KB
Volume: 37
Category: Article
ISSN: 1071-5762
DOI: 10.1080/1071576031000090019

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## Abstract In the present work we investigated the in vitro effect of 3‐hydroxy‐3‐methylglutarate (HMG) that accumulates in 3‐hydroxy‐3‐methylglutaryl‐CoA lyase deficiency (HMGLD) on important parameters of oxidative stress in rat cerebral cortex. It was observed that HMG induced lipid peroxidatio