Oxidative Damage in Muscular Dystrophy Correlates with the Severity of the Pathology: Role of Glutathione Metabolism
β Scribed by R. Renjini; N. Gayathri; A. Nalini; M. M. Srinivas Bharath
- Publisher
- Springer
- Year
- 2012
- Tongue
- English
- Weight
- 778 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0364-3190
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## Abstract Although the genetic and biochemical bases of many of the muscular dystrophies have been elucidated, the pathophysiological mechanisms leading to muscle cell death and degeneration remain elusive. Among the most well studied of the dystrophies are those due to defects in proteins that m
Autoradiography with the nitric oxide synthase (NOS) inhibitor ( 3 H)nitro-L-arginine ([ 3 H]L-NNA) was used to quantify NOS in cervical and lumbar spinal cord in normal and dystrophic mice. A single homogeneous population of binding sites was seen in all subregions of the gray matter in normal mice