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Oxidation of Methionine to Dehydromethionine by Reactive Halogen Species Generated by Neutrophils

✍ Scribed by Peskin, Alexander V.; Turner, Rufus; Maghzal, Ghassan J.; Winterbourn, Christine C.; Kettle, Anthony J.


Book ID
120073680
Publisher
American Chemical Society
Year
2009
Tongue
English
Weight
862 KB
Volume
48
Category
Article
ISSN
0006-2960

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The oxidation of methionine plays an important role in vivo, during biological conditions of oxidative stress, as well as for protein stability in vitro. Depending on the nature of the oxidizing species, methionine may undergo a two-electron oxidation to methionine sulfoxide or oneelectron oxidation