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Reactive intermediates in the oxidation of hydralazine by HOCl: the major oxidant generated by neutrophils

✍ Scribed by Angela H. Hofstra; Jack P. Uetrecht

Book ID
113137598
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
666 KB
Volume
89
Category
Article
ISSN
0009-2797

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## Abstract A series of substituted 4‐methylphenols **1** and **2** was oxidized with PbO~2~ in the presence of nitroso compounds **3**–**10**. The formation of adducts of benzyl radicals with the nitroso spin traps in the reaction mixture was established, suggesting the abstraction of an H‐atom fr