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Oxidation of Indole and Indole Derivatives Catalyzed by Nonheme Chloroperoxidases

โœ Scribed by V. N. Burd; R. Bantleon; K.-H. van Pee


Book ID
110288384
Publisher
SP MAIK Nauka/Interperiodica
Year
2001
Tongue
English
Weight
31 KB
Volume
37
Category
Article
ISSN
0003-6838

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Direct C2-trifluoromethylation of indole
โœ Ryo Shimizu; Hiromichi Egami; Tatsuya Nagi; Jungha Chae; Yoshitaka Hamashima; Mi ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 306 KB

Direct C2-selective trifluoromethylation of indole derivatives was achieved with Togni's hypervalent iodine reagent and CuOAc as a catalyst in MeOH under mild conditions, affording the desired C2-trifluoromethylated indoles in good yield (up to 90%).