Direct C2-trifluoromethylation of indole derivatives catalyzed by copper acetate

✍ Scribed by Ryo Shimizu; Hiromichi Egami; Tatsuya Nagi; Jungha Chae; Yoshitaka Hamashima; Mikiko Sodeoka

• Book ID: 104098315
• Publisher: Elsevier Science
• Year: 2010
• Tongue: French
• Weight: 306 KB
• Volume: 51
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2010.09.027

✦ Synopsis

Direct C2-selective trifluoromethylation of indole derivatives was achieved with Togni's hypervalent iodine reagent and CuOAc as a catalyst in MeOH under mild conditions, affording the desired C2-trifluoromethylated indoles in good yield (up to 90%).