Oxcarbazepine disposition: Preliminary observations in patients

✍ Scribed by A. Kumps; C. Wurth

• Book ID: 101702372
• Publisher: John Wiley and Sons
• Year: 1990
• Tongue: English
• Weight: 220 KB
• Volume: 11
• Category: Article
• ISSN: 0142-2782
• DOI: 10.1002/bdd.2510110405

✦ Synopsis

We describe a preliminary retrospective study based on the concentration of two hydroxylated metabolites of oxcarbazepine (OCZ), a new anticonvulsant substance, measured in the plasma of 15 patients with epilepsy. Their ages ranged from 8 to 68 years, 6 of them also received phenobarbital and/or phenytoin as co-medication. The concentration of 10-hydroxy-10,ll-dihydrocarbamazepine (HCBZ) or of trans-10,lldihydroxy-l0,ll-dihydrocarbamazepine (DHCBZ), the metabolites measured, are significantly correlated with the dose of OCZ (p < 0.05 a n d p < 0.01, respectively). DHCBZ